HCID 68547156, compound → HCID 68546525, compound

HRID 1432085Notes

Reaction equation

HRID 1432085 reaction equation
[C:1]([O:5][C:6](=[O:35])[NH:7][C@H:8]1[CH2:23][CH2:22][CH2:21][CH:20]=[CH:19][CH2:18][CH2:17][C@@H:16]([CH3:24])[CH2:15][C@@H:14]([C@@H:25]2[CH2:29][C@@H:28]([CH3:30])[C:27](=[O:31])[O:26]2)[NH:13][C:12](=[O:32])[C@H:11]([CH3:33])[NH:10][C:9]1=[O:34])([CH3:4])([CH3:3])[CH3:2]>C(N)CCC>[C:1]([O:5][C:6](=[O:35])[NH:7][C@H:8]1[CH2:23][CH2:22][CH2:21][CH:20]=[CH:19][CH2:18][CH2:17][C@@H:16]([CH3:24])[CH2:15][C@@H:14]([C@@H:25]([OH:26])[CH2:29][C@H:28]([C:27](=[O:31])[NH:7][CH2:8][CH2:23][CH2:22][CH3:21])[CH3:30])[NH:13][C:12](=[O:32])[C@H:11]([CH3:33])[NH:10][C:9]1=[O:34])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 68547156HCID 68547156, compound

Product 1

HCID 68546525HCID 68546525, compound

Reagents, catalysts & solvents 1

HCID 8007ButylamineSolvent

Procedure

A solution of 183 mg (0.37 mmol) [(3S,6S,14R,16S)-3,14-dimethyl-16-((2S,4R)-4-methyl-5-oxo-tetrahydro-furan-2-yl)-2,5-dioxo-1,4diaza-cyclohexadec-10-en-6-yl]-carbamic acid tert-butyl ester in 1.5 ml butylamine is heated to 65° C. under nitrogen for two hours. The reaction mixture is evaporated, the residue taken up in toluene and evaporated to dryness to yield the title compound.

Workup

  1. customThe reaction mixture is evaporated
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-73130bad3a864a18a46970c8be33d20d
Source dataset
uspto-grants-2009_11
Patent number
US07612055B2

Reaction notes

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