HCID 68544807, compound → HCID 68544322, compound

HRID 1432093Notes

Reaction equation

HRID 1432093 reaction equation
[CH3:1][O:2][C:3]1[N:19]=[C:18]2[CH:20]=[C:5]([C:6](=[O:29])[NH:7][CH:8]([CH:22]3[CH2:26][CH:25]([CH3:27])[C:24](=[O:28])[O:23]3)[CH2:9][CH:10]([CH3:21])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17]2)[CH:4]=1>C(N)CCC>[CH2:6]([NH:7][C:24](=[O:28])[CH:25]([CH3:27])[CH2:26][CH:22]([OH:23])[CH:8]1[NH:7][C:6](=[O:29])[C:5]2=[CH:20][C:18](=[N:19][C:3]([O:2][CH3:1])=[CH:4]2)[NH:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][C@@H:10]([CH3:21])[CH2:9]1)[CH2:5][CH2:4][CH3:3]

Participants

3

Reactant 1

HCID 68544807HCID 68544807, compound

Product 1

HCID 68544322HCID 68544322, compound

Reagents, catalysts & solvents 1

HCID 8007ButylamineSolvent

Procedure

A solution of 16-methoxy-9-methyl-11-(4-methyl-5-oxo-tetrahydro-furan-2-yl)-2,12,17-triaza-bicyclo[12.3.1]octadeca-1(17),14(18),15-trien-13-one (49 mg, 0.12 mmol) in 1.2 ml butylamine is stirred at 50° for 3 h. Excess butylamine is evaporated and the residue purified by chromatography on silica gel to afford the title compound (mixture of diastereomers) as a slightly yellow powder.

Workup

  1. customExcess butylamine is evaporated
  2. customthe residue purified by chromatography on silica gel

Sources & evidence

ORD record
ord-dc031ec82adf4757baffba86b56f6072
Source dataset
uspto-grants-2009_11
Patent number
US07612055B2

Reaction notes

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