反应详情

To a solution of 6.48 g (21 mmol) (S)-3(3-bromo-5-methyl-benzylsulfanyl)-2-methyl-propionic acid in 70 ml acetonitrile and 35 ml water is added 65.7 g (107 mmol) oxone®. After stirring for 2.5 hrs at rt the mixture is diluted with EtOAc and water to get a clear solution. The organic layer is washed with brine, dried over magnesium sulfate and the solvent is evaporated. Crystallization from DCM/diethyl ether and a little methanol gives the title compound as white crystals.

1. customto get a clear solution
2. washThe organic layer is washed with brine
3. dry with materialdried over magnesium sulfate
4. customthe solvent is evaporated
5. customCrystallization from DCM/diethyl ether