Hydrochloric Acid → HCID 68541529, compound

HRID 1432113Notes

Reaction equation

HRID 1432113 reaction equation
C[O:2][C:3](=[O:27])[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[C:6]([N:12]([C:17]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:18])[CH2:13][CH2:14][CH:15]=[CH2:16])[CH:5]=1.[OH-].[Na+].Cl>CO>[CH2:20]([O:19][C:17]([N:12]([CH2:13][CH2:14][CH:15]=[CH2:16])[C:6]1[CH:5]=[C:4]([CH:9]=[C:8]([O:10][CH3:11])[CH:7]=1)[C:3]([OH:27])=[O:2])=[O:18])[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68541742HCID 68541742, compound

Product 1

HCID 68541529HCID 68541529, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This ester (118 mg, 0.32 mmol) is dissolved in 2 ml MeOH and treated with 2 ml 1N NaOH for 18 h. The mixture is acidified with 1 N HCl and extracted with EtOAc. The organic phase is dried with sodium sulfate and evaporated to yield the title compound.

Workup

  1. extractionextracted with EtOAc
  2. dry with materialThe organic phase is dried with sodium sulfate
  3. customevaporated

Sources & evidence

ORD record
ord-9890fec299ac4e30b3fe9850d5955e21
Source dataset
uspto-grants-2009_11
Patent number
US07612055B2

Reaction notes

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