HCID 68539176, compound → HCID 68541975, compound

HRID 1432114Notes

Reaction equation

HRID 1432114 reaction equation
C([O:5][C:6](=[O:22])[C:7]1[CH:12]=[C:11]([NH:13][CH2:14][CH2:15][CH2:16][CH:17]=[CH2:18])[N:10]=[C:9]([O:19][CH2:20][CH3:21])[CH:8]=1)(C)(C)C>FC(F)(F)C(O)=O>[CH2:20]([O:19][C:9]1[CH:8]=[C:7]([CH:12]=[C:11]([NH:13][CH2:14][CH2:15][CH2:16][CH:17]=[CH2:18])[N:10]=1)[C:6]([OH:22])=[O:5])[CH3:21]

Participants

3

Reactant 1

HCID 68539176HCID 68539176, compound

Product 1

HCID 68541975HCID 68541975, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

The title compound is prepared by stirring 2-ethoxy-6-pent-4-enylamino-isonicotinic acid tert-butyl ester 18 h in neat trifluoroacetic acid. Evaporation of the TFA gives the title compound that is used in the next step without purification.

Workup

  1. customThe title compound is prepared
  2. customEvaporation of the TFA

Sources & evidence

ORD record
ord-e762e36c008e4bf2b4fa0005d6340865
Source dataset
uspto-grants-2009_11
Patent number
US07612055B2

Reaction notes

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