Trifluoroacetic acid → HCID 68541378, compound

HRID 1432115Notes

Reaction equation

HRID 1432115 reaction equation
C([O:5][C:6](=[O:22])[C:7]1[CH:12]=[C:11]([NH:13][CH2:14][CH2:15][CH2:16][CH:17]=C)[N:10]=[C:9]([O:19][CH2:20]C)[CH:8]=1)(C)(C)C.F[C:24](F)(F)[C:25](O)=O>>[CH2:24]([CH:14]([NH:13][C:11]1[CH:12]=[C:7]([CH:8]=[C:9]([O:19][CH3:20])[N:10]=1)[C:6]([OH:5])=[O:22])[CH2:15][CH:16]=[CH2:17])[CH3:25]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68539176HCID 68539176, compound

Product 1

HCID 68541378HCID 68541378, compound

Procedure

The title compound is prepared by stirring 2-ethoxy-6-pent-4-enylamino-isonicotinic acid tert-butyl ester 18 h in neat trifluoroacetic acid. Evaporation of the TFA gives the title compound that is used in the next step without purification.

Workup

  1. customThe title compound is prepared
  2. customEvaporation of the TFA

Sources & evidence

ORD record
ord-ea00e9b8ebe84cf1b085ee48a0cc1f46
Source dataset
uspto-grants-2009_11
Patent number
US07612055B2

Reaction notes

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