Succinic anhydride → HCID 86052087, compound

HRID 1432127Notes

Reaction equation

HRID 1432127 reaction equation
[CH2:1]([NH2:5])[CH2:2][CH:3]=[CH2:4].[C:6]1(=[O:12])[O:11][C:9](=[O:10])[CH2:8][CH2:7]1.[OH-].[Na+]>C(Cl)Cl>[CH2:1]([NH:5][C:6](=[O:12])[CH2:7][CH2:8][C:9]([OH:11])=[O:10])[CH2:2][CH:3]=[CH2:4]

Participants

5

Reactant 3

HCID 7922Succinic anhydrideHCID 14798Sodium HydroxideHCID 4437323-Buten-1-amine

Product 1

HCID 86052087HCID 86052087, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 0.71 g (10 mmol) but-3-enylamine and 1.0 g (10 mmol) succinic anhydride in 10 ml DCM is stirred for 16 h. The mixture is poured into 25 ml 1N NaOH, washed with TBME, acidified with 6 ml 6N HCl, saturated with NaCl and extracted with THF/EtOAc twice. The combined organic layers are dried with sodium sulfate and evaporated to yield the title compound.

Workup

  1. washwashed with TBME
  2. extractionextracted with THF/EtOAc twice
  3. dry with materialThe combined organic layers are dried with sodium sulfate
  4. customevaporated

Sources & evidence

ORD record
ord-49217f6180c340568e2b710bcf0b7e57
Source dataset
uspto-grants-2009_11
Patent number
US07612055B2

Reaction notes

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