Water → HCID 15486854, compound

HRID 1432206Notes

Reaction equation

HRID 1432206 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:18](S(C2C=CC=CC=2)(=O)=O)[C:9]2=[N:10][CH:11]=[C:12]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:13]=[C:8]2[CH:7]=1.[OH-].[K+].O>O1CCCC1.O1CCOCC1>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[NH:18][C:9]2=[N:10][CH:11]=[C:12]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:13]=[C:8]2[CH:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 15486853HCID 15486853, compound

Product 1

HCID 15486854HCID 15486854, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 22018518Dioxane tetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of the compound obtained in the step of Example 1 (3) (675 mg) in a mixture of tetrahydrofuran/dioxane (5:1, 120 ml), a 1N aqueous potassium hydroxide solution (5 ml) was added-and the mixture was stirred at 60° C. for 15 hours. The reaction solution was then poured into water, extracted with ethyl-acetate, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to obtain 431 mg. (98%) of the desired product as a brown powder.

Workup

  1. extractionextracted with ethyl-acetate
  2. dry with materialdried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customto obtain 431 mg

Sources & evidence

ORD record
ord-d3e29a2d7714429aa244d5244e0fa9ae
Source dataset
uspto-grants-2009_11
Patent number
US07612070B2

Reaction notes

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