Water → HCID 15486854, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the compound obtained in the step of Example 1 (3) (675 mg) in a mixture of tetrahydrofuran/dioxane (5:1, 120 ml), a 1N aqueous potassium hydroxide solution (5 ml) was added-and the mixture was stirred at 60° C. for 15 hours. The reaction solution was then poured into water, extracted with ethyl-acetate, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to obtain 431 mg. (98%) of the desired product as a brown powder.

Provenance & Evidence