Hydrochloric Acid → HCID 12094551, compound

HRID 1432242Notes

Reaction equation

HRID 1432242 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[CH:8][C:9]([C:12]2[N:13]([CH2:25][C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=3)[C:14]3[C:19]([CH:20]=2)=[CH:18][C:17]([S:21]([CH3:24])(=[O:23])=[O:22])=[CH:16][CH:15]=3)=[N:10][CH:11]=1)=[O:5])C.[OH-].[K+].CO.Cl>O>[F:32][C:29]1[CH:28]=[CH:27][C:26]([CH2:25][N:13]2[C:14]3[C:19](=[CH:18][C:17]([S:21]([CH3:24])(=[O:22])=[O:23])=[CH:16][CH:15]=3)[CH:20]=[C:12]2[C:9]2[CH:8]=[CH:7][C:6]([C:4]([O:3][CH3:1])=[O:5])=[CH:11][N:10]=2)=[CH:31][CH:30]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14797Potassium HydroxideHCID 22504405HCID 22504405, compound

Product 1

HCID 12094551HCID 12094551, compoundYield 66.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
22.5 °C

Procedure

A mixture of 2-(5-ethoxycarbonylpyridin-2-yl)-1-(4-fluorobenzyl)-5-methanesulfonylindole (0.68 g), potassium hydroxide (0.24 g) and methanol (45 ml) was stirred at 15 to 30° C. for 30 minutes under nitrogen atmosphere. To the reaction solution was added water and the mixture was neutralized with hydrochloric acid. The precipitated crystal was filtered off. The resulting crude crystal was recrystallized (methanol) to obtain 0.44 g of the desired product.

Workup

  1. filtrationThe precipitated crystal was filtered off
  2. customThe resulting crude crystal was recrystallized (methanol)

Sources & evidence

ORD record
ord-3480e8ee2da34a31bbe71105217e95e7
Source dataset
uspto-grants-2009_11
Patent number
US07612070B2

Reaction notes

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