HCID 22504411, compound → HCID 22504424, compound

HRID 1432284Notes

Reaction equation

HRID 1432284 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[C:9][CH2:10][OH:11])=[N:6][C:5]([S:12][CH3:13])=[CH:4][N:3]=1>CC(C)=O.[O-2].[O-2].[Mn+4]>[CH3:13][S:12][C:5]1[N:6]=[C:7]2[CH:8]=[C:9]([CH:10]=[O:11])[NH:1][C:2]2=[N:3][CH:4]=1

Participants

4

Reactant 1

HCID 22504411HCID 22504411, compound

Product 1

HCID 22504424HCID 22504424, compoundYield 49.3%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 180AcetoneSolvent

Conditions

Temperature
7.5 °C

Procedure

To a solution of the compound obtained in Example 34 (4) (123 mg) in acetone (40 ml), manganese dioxide (1.86 g) was added and the mixture was stirred at −15 to 30° C. for-1 hour. The reaction solution was filtered through Celite and concentrated under reduced pressure to obtain 60 mg (49.3%) of the desired product as a yellow powder.

Workup

  1. filtrationThe reaction solution was filtered through Celite
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-c3d215e93b0f43cd877000387b2f0884
Source dataset
uspto-grants-2009_11
Patent number
US07612070B2

Reaction notes

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