反应详情

温度

80 °C

A suspension of (3-Benzyloxy-phenyl)-acetaldehyde (20.6 g, 91 mmol), tert-butylcarbamate (10.7 g, 91 mmol, 1 eq), sodium benzenesulfinate (18.3 g, 109 mmol, 1.2 eq) and formic acid (5.2 ml, 137 mmol, 1.5 eq) in 155 ml acetonitrile is stirred at 80° C. for 4 h. After cooling to rt the mixture is taken up in EtOAc. The solution is washed with bicarbonate and brine, dried over magnesium sulfate and evaporated. The residue (37.3 g) is used for the next step without further purification.

1. temperatureAfter cooling to rt the mixture
2. washThe solution is washed with bicarbonate and brine
3. dry with materialdried over magnesium sulfate
4. customevaporated
5. customThe residue (37.3 g) is used for the next step without further purification