Hydrochloric Acid → (1S,2S,4R*)-1-(3-Benzyloxy-benzyl)-4-butylcarbamoyl-2-hydroxy-pentyl-ammonium chloride

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	[(1S,2S,4R*)-1-(3-Benzyloxy-benzyl)-4-butylcarbamoyl-2-hydroxy-pentyl]-carbamic acid tert-butyl ester	HCID 11648991	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	(1S,2S,4R*)-1-(3-Benzyloxy-benzyl)-4-butylcarbamoyl-2-hydroxy-pentyl-ammonium chloride	HCID 86612512	—

Reaction Steps

[(1S*,2S*,4R*)-1-(3-Benzyloxy-benzyl)-4-butylcarbamoyl-2-hydroxy-pentyl]-carbamic acid tert-butyl ester (660 mg, 1.3 mmol) is dissolved in 4M HCl in dioxane (14 ml) and stirred at rt for 75 min. Evaporation of the solvent and washing the residue with diethyl ether gives a white foam (535 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07612054B2
Source dataset	uspto-grants-2009_11
ORD ID	ord-1fd598161b924e2baf87aa08e53ab8b1
Source note	uspto-grants-2009_11