Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diphosgene | HCID 10426 | — |
| Reactant | Trifluoroacetate | HCID 84468 | — |
| Reactant | HCID 66870407 | HCID 66870407 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 66870786 | HCID 66870786 | — |
Reaction Steps
0.802 g (2.034 mmoles) of the trifluoroacetate of cis(4-nitrophenyl)methyl 5-hydroxy-2-piperidinecarboxylate (described in Rec. Trav. Chim. (1959), 78, 648-658), of molecular formula C13H16N2O5,CF3CO2H (M=394.303 g) is introduced under a nitrogen atmosphere, into 40 ml of dichloromethane and the reaction medium is cooled down to 0° C. 0.135 ml of diphosgene is added. Agitation is carried out for 15 minutes at 0° C., the temperature is left to rise to ambient temperature and agitation is continued for 35 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07612087B2 |
|---|
| Source dataset | uspto-grants-2009_11 |
|---|
| ORD ID | ord-d91fabb7d6024ba8b40ffb239a736bf7 |
|---|
| Source note | uspto-grants-2009_11 |
|---|
