Hydrochloric Acid → Hydroxyterfenadine

HRID 143239Notes

Reaction equation

HRID 143239 reaction equation
[BH4-:37].[CH3:40][OH:41].[ClH:39].[Na+:38].[O:1]=[C:2]([CH2:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][CH:9]([C:12]([c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)([c:19]2[cH:20][cH:21][cH:22][cH:23][cH:24]2)[OH:25])[CH2:10][CH2:11]1)[c:26]1[cH:27][cH:28][c:29]([C:32]([CH2:33][OH:34])([CH3:35])[CH3:36])[cH:30][cH:31]1.[OH2:42]>>[OH:1][CH:2]([CH2:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][CH:9]([C:12]([c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)([c:19]2[cH:20][cH:21][cH:22][cH:23][cH:24]2)[OH:25])[CH2:10][CH2:11]1)[c:26]1[cH:27][cH:28][c:29]([C:32]([CH2:33][OH:34])([CH3:35])[CH3:36])[cH:30][cH:31]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 887MethanolHCID 923Sodium ionHCID 962WaterHCID 28123BorohydrideHCID 118129062-(4-(1-Oxo-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)-butyl)-phenyl)-2-methylpropanol

Product 1

HCID 9805485Hydroxyterfenadine

Sources & evidence

ORD record
ord-8d47f48ece4240a1b2599a6ec209a4c8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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