Benzaldehyde → HCID 57933463, compound

HRID 1432453Notes

Reaction equation

HRID 1432453 reaction equation
[OH:1][C:2]1[CH:6]([CH:7]([CH3:9])[CH3:8])[NH:5][C:4](=[O:10])[CH:3]=1.[CH:11](=O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[F:19][C:20]1[CH:21]=[C:22]2[C:26](=[CH:27][CH:28]=1)[NH:25][CH:24]=[C:23]2[CH:29]([CH3:31])[CH3:30]>>[F:19][C:20]1[CH:21]=[C:22]2[C:26](=[CH:27][CH:28]=1)[NH:25][C:24]([CH:11]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:3]1[C:4](=[O:10])[NH:5][CH:6]([CH:7]([CH3:9])[CH3:8])[C:2]=1[OH:1])=[C:23]2[CH:29]([CH3:31])[CH3:30]

Participants

4

Reactant 3

HCID 240BenzaldehydeHCID 566041114-Hydroxy-5-isopropyl-1,5-dihydro-pyrrol-2-oneHCID 58657515HCID 58657515, compound

Product 1

HCID 57933463HCID 57933463, compound

Procedure

Using general procedure C, 4-hydroxy-5-isopropyl-1,5-dihydro-pyrrol-2-one (Lit. 11) was reacted with benzaldehyde and 5-fluoro-3-isopropyl-1H-indole to give 3-[(5-fluoro-3-isopropyl-1H-indol-2-yl)-phenyl-methyl]-4-hydroxy-5-isopropyl-1,5-dihydro-pyrrol-2-one as a orange solid. MS: 405.2 ([M−H]−).

Sources & evidence

ORD record
ord-3c0f340598c84b2c8dc6b7d08d985ffa
Source dataset
uspto-grants-2009_11
Patent number
US07612099B2

Reaction notes

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