Benzaldehyde → N-[2-(2-{[5-(2-Cyclohexyl-ethyl)-4-hydroxy-2-oxo-2,5-dihydro-furan-3-yl]-phenyl-methyl}-6-fluoro-1H-indol-3-yl)-ethyl]-acetamide

Participants

Role	Name	HCID	Charge
Reactant	Benzaldehyde	HCID 240	—
Reactant	N-[2-(6-Fluoro-1H-indol-3-yl)-ethyl]-acetamide	HCID 10751398	—
Reactant	5-(2-cyclohexyl-ethyl)-4-hydroxy-5H-furan-2-one	HCID 69069334	—
Product	N-[2-(2-{[5-(2-Cyclohexyl-ethyl)-4-hydroxy-2-oxo-2,5-dihydro-furan-3-yl]-phenyl-methyl}-6-fluoro-1H-indol-3-yl)-ethyl]-acetamide	HCID 57933469	—

Reaction Steps

Using general procedure C, 5-(2-cyclohexyl-ethyl)-4-hydroxy-5H-furan-2-one (Example B2) was reacted with benzaldehyde and N-[2-(6-fluoro-1H-indol-3-yl)-ethyl]-acetamide (Example 18.1.) to give the title compound as pale green solid. MS: 517.2 ([M−H]−).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07612099B2
Source dataset	uspto-grants-2009_11
ORD ID	ord-8a2c29cc2d344b00a413c6d4141afabf
Source note	uspto-grants-2009_11