HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → N-(2-{6-Fluoro-2-[(4-hydroxy-2-oxo-5-phenethyl-2,5-dihydro-furan-3-yl)-phenyl-methyl]-1H-indol-3-yl}-ethyl)-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | N-[2-(6-Fluoro-1H-indol-3-yl)-ethyl]-acetamide | HCID 10751398 | — |
| Reactant | 4-hydroxy-5-phenethyl-5H-furan-2-one | HCID 69069036 | — |
| Product | N-(2-{6-Fluoro-2-[(4-hydroxy-2-oxo-5-phenethyl-2,5-dihydro-furan-3-yl)-phenyl-methyl]-1H-indol-3-yl}-ethyl)-acetamide | HCID 57933412 | — |
Reaction Steps
Using general procedure C, 4-hydroxy-5-phenethyl-5H-furan-2-one (Lit. 13) was reacted with benzaldehyde and N-[2-(6-fluoro-1H-indol-3-yl)-ethyl]-acetamide (Example 18.1.) to give the title compound as pale red solid. MS: 511.1 ([M−H]−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612099B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-6c978e8a46664042956d953760115196 |
| Source note | uspto-grants-2009_11 |