HRID1432476

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID240

Benzaldehyde

C7H6O

HCID10751398

未命名化合物

HCID69069036

未命名化合物

PRODUCTS

生成物

结构：CC(=O)NCCc1c(C(C2=C(O)C(CCc3ccccc3)OC2=O)c2ccccc2)[nH]c2cc(F)ccc12

HCID57933412

未命名化合物

PROCEDURE

实验过程

Using general procedure C, 4-hydroxy-5-phenethyl-5H-furan-2-one (Lit. 13) was reacted with benzaldehyde and N-[2-(6-fluoro-1H-indol-3-yl)-ethyl]-acetamide (Example 18.1.) to give the title compound as pale red solid. MS: 511.1 ([M−H]−).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6c978e8a46664042956d953760115196
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07612099B2
来源说明: uspto-grants-2009_11

反应 SMILES

[OH:1][C:2]1[CH:6]([CH2:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[O:5][C:4](=[O:15])[CH:3]=1.[CH:16](=O)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[F:24][C:25]1[CH:33]=[C:32]2[C:28]([C:29]([CH2:34][CH2:35][NH:36][C:37](=[O:39])[CH3:38])=[CH:30][NH:31]2)=[CH:27][CH:26]=1>>[F:24][C:25]1[CH:33]=[C:32]2[C:28]([C:29]([CH2:34][CH2:35][NH:36][C:37](=[O:39])[CH3:38])=[C:30]([CH:16]([C:3]3[C:4](=[O:15])[O:5][CH:6]([CH2:7][CH2:8][C:9]4[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=4)[C:2]=3[OH:1])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[NH:31]2)=[CH:27][CH:26]=1