Benzaldehyde → N-[2-(6-Fluoro-2-{[4-hydroxy-2-oxo-5-(3-phenyl-propyl)-2,5-dihydro-furan-3-yl]-phenyl-methyl}-1H-indol-3-yl)-ethyl]-acetamide

Participants

Role	Name	HCID	Charge
Reactant	Benzaldehyde	HCID 240	—
Reactant	N-[2-(6-Fluoro-1H-indol-3-yl)-ethyl]-acetamide	HCID 10751398	—
Reactant	4-hydroxy-5-(3-phenyl-propyl)-5H-furan-2-one	HCID 69066807	—
Product	N-[2-(6-Fluoro-2-{[4-hydroxy-2-oxo-5-(3-phenyl-propyl)-2,5-dihydro-furan-3-yl]-phenyl-methyl}-1H-indol-3-yl)-ethyl]-acetamide	HCID 57933466	—

Reaction Steps

Using general procedure C, 4-hydroxy-5-(3-phenyl-propyl)-5H-furan-2-one (Lit. 13) was reacted with benzaldehyde and N-[2-(6-fluoro-1H-indol-3-yl)-ethyl]-acetamide (Example 18.1.) to give the title compound as pale red solid. MS: 525.2 ([M−H]−).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07612099B2
Source dataset	uspto-grants-2009_11
ORD ID	ord-e32cf092ef92429ca13e9584279e8758
Source note	uspto-grants-2009_11