HRID1432477

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID240

Benzaldehyde

C7H6O

HCID10751398

未命名化合物

HCID69066807

未命名化合物

PRODUCTS

生成物

结构：CC(=O)NCCc1c(C(C2=C(O)C(CCCc3ccccc3)OC2=O)c2ccccc2)[nH]c2cc(F)ccc12

HCID57933466

未命名化合物

PROCEDURE

实验过程

Using general procedure C, 4-hydroxy-5-(3-phenyl-propyl)-5H-furan-2-one (Lit. 13) was reacted with benzaldehyde and N-[2-(6-fluoro-1H-indol-3-yl)-ethyl]-acetamide (Example 18.1.) to give the title compound as pale red solid. MS: 525.2 ([M−H]−).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e32cf092ef92429ca13e9584279e8758
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07612099B2
来源说明: uspto-grants-2009_11

反应 SMILES

[OH:1][C:2]1[CH:6]([CH2:7][CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[O:5][C:4](=[O:16])[CH:3]=1.[CH:17](=O)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[F:25][C:26]1[CH:34]=[C:33]2[C:29]([C:30]([CH2:35][CH2:36][NH:37][C:38](=[O:40])[CH3:39])=[CH:31][NH:32]2)=[CH:28][CH:27]=1>>[F:25][C:26]1[CH:34]=[C:33]2[C:29]([C:30]([CH2:35][CH2:36][NH:37][C:38](=[O:40])[CH3:39])=[C:31]([CH:17]([C:3]3[C:4](=[O:16])[O:5][CH:6]([CH2:7][CH2:8][CH2:9][C:10]4[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=4)[C:2]=3[OH:1])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[NH:32]2)=[CH:28][CH:27]=1