Benzaldehyde → HCID 57933452, compound

HRID 1432494Notes

Reaction equation

HRID 1432494 reaction equation
[OH:1][C:2]1[CH:6]([CH:7]([CH3:9])[CH3:8])[NH:5][C:4](=[O:10])[CH:3]=1.[CH:11](=O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[F:19][C:20]1[CH:28]=[C:27]2[C:23]([C:24]([CH2:29][CH2:30][OH:31])=[CH:25][NH:26]2)=[CH:22][CH:21]=1>>[F:19][C:20]1[CH:28]=[C:27]2[C:23]([C:24]([CH2:29][CH2:30][OH:31])=[C:25]([CH:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:3]3[C:4](=[O:10])[NH:5][CH:6]([CH:7]([CH3:9])[CH3:8])[C:2]=3[OH:1])[NH:26]2)=[CH:22][CH:21]=1

Participants

4

Reactant 3

HCID 240BenzaldehydeHCID 122728176-Fluoro-1H-indole-3-ethanolHCID 566041114-Hydroxy-5-isopropyl-1,5-dihydro-pyrrol-2-one

Product 1

HCID 57933452HCID 57933452, compound

Procedure

Using general procedure D, rac-4-hydroxy-5-isopropyl-1,5-dihydro-pyrrol-2-one (Lit. 11) was reacted with benzaldehyde and 2-(6-fluoro-1H-indol-3-yl)-ethanol to give the title compound as a pale yellow solid. MS: 409.1 ([M+H]+).

Sources & evidence

ORD record
ord-00740c45c513449db52ed4dce5257721
Source dataset
uspto-grants-2009_11
Patent number
US07612099B2

Reaction notes

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