Benzaldehyde → HCID 57933478, compound

HRID 1432495Notes

Reaction equation

HRID 1432495 reaction equation
[OH:1][C:2]1[C:9]2([CH3:10])[N:5]([CH2:6][CH2:7][CH2:8]2)[C:4](=[O:11])[CH:3]=1.[CH:12](=O)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[F:20][C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[NH:26][CH:25]=[C:24]2[CH3:30]>>[F:20][C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[NH:26][C:25]([CH:12]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:3]1[C:4](=[O:11])[N:5]3[C:9]([CH3:10])([CH2:8][CH2:7][CH2:6]3)[C:2]=1[OH:1])=[C:24]2[CH3:30]

Participants

4

Reactant 3

HCID 240BenzaldehydeHCID 223515035-Fluoro-3-methyl-1H-indoleHCID 69066221HCID 69066221, compound

Product 1

HCID 57933478HCID 57933478, compound

Procedure

Using general procedure D, rac-1-hydroxy-7a-methyl-5,6,7,7a-tetrahydro-pyrrolizin-3-one (Example C) was reacted with benzaldehyde and 5-fluoro-3-methyl-1H-indole to give the title compound as a red solid. MS: 391.1 ([M+H]+).

Sources & evidence

ORD record
ord-3693bfb101ed4889aecb6b20d1b819bd
Source dataset
uspto-grants-2009_11
Patent number
US07612099B2

Reaction notes

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