Benzaldehyde → HCID 57933471, compound

HRID 1432497Notes

Reaction equation

HRID 1432497 reaction equation
[CH2:1]([C@@:8]1([CH3:15])[NH:12][C:11](=[O:13])[CH:10]=[C:9]1[OH:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:16](=O)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[F:24][C:25]1[CH:26]=[C:27]2[C:31](=[CH:32][CH:33]=1)[NH:30][CH:29]=[C:28]2[CH3:34]>>[CH2:1]([C@@:8]1([CH3:15])[NH:12][C:11](=[O:13])[C:10]([CH:16]([C:29]2[NH:30][C:31]3[C:27]([C:28]=2[CH3:34])=[CH:26][C:25]([F:24])=[CH:33][CH:32]=3)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:9]1[OH:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 240BenzaldehydeHCID 223515035-Fluoro-3-methyl-1H-indoleHCID 69072534HCID 69072534, compound

Product 1

HCID 57933471HCID 57933471, compound

Procedure

Using general procedure D, (R)-5-benzyl-4-hydroxy-5-methyl-1,5-dihydro-pyrrol-2-one (Example D) was reacted with benzaldehyde and 5-fluoro-3-methyl-1H-indole to give the title compound as a yellow solid. MS: 441.1 ([M+H]+).

Sources & evidence

ORD record
ord-4d3ec9b939b54680ba137dcebe779379
Source dataset
uspto-grants-2009_11
Patent number
US07612099B2

Reaction notes

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