Benzaldehyde → HCID 57933415, compound

HRID 1432498Notes

Reaction equation

HRID 1432498 reaction equation
[OH:1][C:2]1[C@:6]([CH:8]([CH3:10])[CH3:9])([CH3:7])[NH:5][C:4](=[O:11])[CH:3]=1.[CH:12](=O)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[F:20][C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[NH:26][CH:25]=[C:24]2[CH3:30]>>[F:20][C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[NH:26][C:25]([CH:12]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:3]1[C:4](=[O:11])[NH:5][C@@:6]([CH:8]([CH3:9])[CH3:10])([CH3:7])[C:2]=1[OH:1])=[C:24]2[CH3:30]

Participants

4

Reactant 3

HCID 240BenzaldehydeHCID 223515035-Fluoro-3-methyl-1H-indoleHCID 69070761HCID 69070761, compound

Product 1

HCID 57933415HCID 57933415, compound

Procedure

Using general procedure D, (R)-4-hydroxy-5-isopropyl-5-methyl-1,5-dihydro-pyrrol-2-one (Example E) was reacted with benzaldehyde and 5-fluoro-3-methyl-1H-indole to give the title compound as a pale yellow solid. MS: 393.1 ([M+H]+).

Sources & evidence

ORD record
ord-a06d5b8276a044a9bb70afe0c939e9d1
Source dataset
uspto-grants-2009_11
Patent number
US07612099B2

Reaction notes

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