Potassium thiocyanate → HCID 87631551, compound

HRID 1432527Notes

Reaction equation

HRID 1432527 reaction equation
[C:1]([S-:3])#N.[K+].[C:5]([NH:12][C@H:13]([C:17]([N:19]1[CH2:24][CH2:23]C=[CH:21][CH2:20]1)=[O:18])[CH:14]([CH3:16])[CH3:15])([O:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:6]>O.CCO>[S:3]1[CH:1]2[CH:21]1[CH2:20][N:19]([C:17](=[O:18])[C@@H:13]([CH:14]([CH3:15])[CH3:16])[NH:12][C:5]([O:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:6])[CH2:24][CH2:23]2

Participants

5

Reactant 2

HCID 516872Potassium thiocyanateHCID 91018714HCID 91018714, compound

Product 1

HCID 87631551HCID 87631551, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

2.91 g of KSCN in 3 ml of H2O are added to a mixture of 5.96 g of 3,4-epoxy-N—(N-BOC-valyl-1,2,5,6-tetrahydropyridine in 10 ml of absolute EtOH and the mixture obtained is stirred for 72 hours at RT. The mixture obtained is subjected to aqueous extraction, the solvent of the organic phase obtained is evaporated and the evaporation residue is subjeted to chromatography. 3,4-Epithio-N(N-BOC-(R)-valyl)-piperidine is obtained. Melting point: 69.71°

Workup

  1. customthe mixture obtained
  2. customThe mixture obtained
  3. extractionis subjected to aqueous extraction
  4. customthe solvent of the organic phase obtained
  5. customis evaporated

Sources & evidence

ORD record
ord-a90d05c126cc4915aee1653c0e37dcc3
Source dataset
uspto-grants-2009_11
Patent number
US07612103B2

Reaction notes

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