HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1432532Generated: October 26, 2026
5-Isopropyl-1,3,4-thiadiazol-2-amine → N-[5-(5-Isopropyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-indan-2-yl]-acetamide
https://huagongshe.com/reaction/1432532
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-Isopropyl-1,3,4-thiadiazol-2-amine | HCID 147151 | — |
| Reactant | 2-Acetamido-2,3-dihydro-1h-indene-5-sulfonyl chloride | HCID 20347856 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-[5-(5-Isopropyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-indan-2-yl]-acetamide | HCID 57933501 | — |
Reaction Steps
2-Acetylamino-indan-5-sulfonyl chloride (500 mg) was dissolved in 5 ml of pyridine and a catalytic amount of 4-dimethylamino pyridine was added. After addition of 262 mg of 5-isopropyl-[1,3,4]thiadiazol-2-ylamine the mixture was stirred at 60° C. for 1 hour followed by evaporation. The resulting crude material was purified by column chromatography (silica gel, eluent: dichloromethane:methanol=95:5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07612104B2 |
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| Source dataset | uspto-grants-2009_11 |
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| ORD ID | ord-ee159bc95827477e88e26ff5296e81ef |
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| Source note | uspto-grants-2009_11 |
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