反应详情

温度

60 °C

2-Acetylamino-indan-5-sulfonyl chloride (500 mg) was dissolved in 5 ml of pyridine and a catalytic amount of 4-dimethylamino pyridine was added. After addition of 262 mg of 5-isopropyl-[1,3,4]thiadiazol-2-ylamine the mixture was stirred at 60° C. for 1 hour followed by evaporation. The resulting crude material was purified by column chromatography (silica gel, eluent: dichloromethane:methanol=95:5).

1. customfollowed by evaporation
2. customThe resulting crude material was purified by column chromatography (silica gel, eluent: dichloromethane:methanol=95:5)