Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chlorophenyl Isocyanate → (4-Chlorophenylaminocarbonyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-6-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chlorophenyl Isocyanate | HCID 7693 | — |
| 반응물 | (RS)-6-Carboxy-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | HCID 12685848 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (4-Chlorophenylaminocarbonyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-6-carboxylic acid | HCID 131727718 | 21.8% |
반응 단계
To a solution of the crude sample 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-6-carboxylic acid (323 mg, 1.77 mmol) in DMF (10 mL), 4-chlorophenyl isocyanate (336 mg, 2.19 mmol) was added. It was stirred at room temperature overnight. After being concentrated in vacuo, the residue was purified by HPLC to give the desired product as a powder (130 mg). MS 337.3 and 339.3 (M+H, Cl pattern)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07612089B2 |
| 출처 데이터셋 | uspto-grants-2009_11 |
| ORD ID | ord-928ac1d13ae74ac1a86cdd0692047a75 |
| 출처 메모 | uspto-grants-2009_11 |