HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 69007062, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Methyl 5-bromothiophene-2-carboxylate | HCID 605713 | — |
| Reactant | HCID 66995493 | HCID 66995493 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 69007062 | HCID 69007062 | — |
Reaction Steps
(3-Cyano-4-benzyloxy-5-fluorophenyl)boronic acid and methyl 5-bromothiophene-2-carboxylate were dissolved in a mixed solution of toluene and a 2 M aqueous sodium carbonate solution and the whole was heated and refluxed for 3 hours in the presence of tetrakis(triphenylphosphine)palladium to obtain methyl 5-(3-cyano-4-benzyloxy-5-fluorophenyl)thiophene-2-carboxylate. F: 368.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612108B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-33b1fa6ceca943f7a07bf0138ab8a4a2 |
| Source note | uspto-grants-2009_11 |