HCID 69007062, compound → HCID 69008032, compound

HRID 1432786Notes

Reaction equation

HRID 1432786 reaction equation
C([O:8][C:9]1[C:14]([F:15])=[CH:13][C:12]([C:16]2[S:20][C:19]([C:21]([O:23][CH3:24])=[O:22])=[CH:18][CH:17]=2)=[CH:11][C:10]=1[C:25]#[N:26])C1C=CC=CC=1>CO.C1COCC1.[C].[Pd]>[C:25]([C:10]1[CH:11]=[C:12]([C:16]2[S:20][C:19]([C:21]([O:23][CH3:24])=[O:22])=[CH:18][CH:17]=2)[CH:13]=[C:14]([F:15])[C:9]=1[OH:8])#[N:26]

Participants

4

Reactant 1

HCID 69007062HCID 69007062, compound

Product 1

HCID 69008032HCID 69008032, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 21899815MeOH tetrahydrofuranSolvent

Procedure

Methyl 5-[4-(benzyloxy)-3-cyano-5-fluorophenyl]thiophene-2-carboxylate was stirred at room temperature in methanol-THF (1:1) under a hydrogen atmosphere at normal pressure in the presence of palladium-carbon to obtain methyl 5-(3-cyano-5-fluoro-4-hydroxyphenyl)thiophene-2-carboxylate. FN: 276.

Sources & evidence

ORD record
ord-d1339e59e04942d3ab16283c6b9654c1
Source dataset
uspto-grants-2009_11
Patent number
US07612108B2

Reaction notes

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