Phenyl isocyanate → HCID 10401518, compound

HRID 1432835Notes

Reaction equation

HRID 1432835 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[CH2:10][CH:9]([OH:12])[CH2:8][CH2:7]2.[C:13]1([N:19]=[C:20]=[O:21])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(OC(C)C)(C)C.CCCCCC>O1CCOCC1>[C:13]1([NH:19][C:20]([NH:1][C:2]2[C:11]3[CH2:10][CH:9]([OH:12])[CH2:8][CH2:7][C:6]=3[CH:5]=[CH:4][CH:3]=2)=[O:21])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

6

Reactant 4

HCID 7672Phenyl isocyanateHCID 7914Diisopropyl EtherHCID 8058HexaneHCID 230669958-Amino-1,2,3,4-tetrahydronaphthalen-2-ol

Product 1

HCID 10401518HCID 10401518, compoundYield 51%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 8-amino-1,2,3,4-tetrahydro-naphthalen-2-ol (20.0 mg, 0.123 mmol) in 1,4-dioxane (1.0 mL) was added phenyl isocyanate. (14.6 mg, 0.123 mmol) at room temperature. The mixture was stirred for 16 hours, and then added diisopropyl ether and hexane. The precipitate was filtered and dried to give N-phenyl-N′-(7-hydroxy-5,6,7,8-tetrahydro-1-naphthalenyl)urea (17.8 mg, 51% yield).

Workup

  1. customat room temperature
  2. filtrationThe precipitate was filtered
  3. customdried

Sources & evidence

ORD record
ord-8b97fac90f574eb7834aefb62eb5bf12
Source dataset
uspto-grants-2009_11
Patent number
US07612113B2

Reaction notes

Loading…