2-[(5-Chlorothiophen-2-yl)oxy]acetic acid → HCID 54424585, compound

HRID 1432982Notes

Reaction equation

HRID 1432982 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:13]3[CH:18]([CH3:19])[CH2:17][NH:16][CH:15]([CH2:20][O:21][CH3:22])[C:14]3=[O:23])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[Cl:24][C:25]1[S:29][C:28]([O:30][CH2:31][C:32](O)=[O:33])=[CH:27][CH:26]=1>>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:13]3[CH:18]([CH3:19])[CH2:17][N:16]([C:32](=[O:33])[CH2:31][O:30][C:28]4[S:29][C:25]([Cl:24])=[CH:26][CH:27]=4)[C@@H:15]([CH2:20][O:21][CH3:22])[C:14]3=[O:23])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 111831442-[(5-Chlorothiophen-2-yl)oxy]acetic acidHCID 179852431-(4-Amino-quinazoline-7-ylmethyl)-3-methoxymethyl-6-methyl-piperazine-2-one

Product 1

HCID 54424585HCID 54424585, compound

Procedure

The title compound is prepared as described in EXAMPLE 123 using 1-(4-amino-quinazoline-7-ylmethyl)-3-methoxymethyl-6-methyl-piperazine-2-one, EXAMPLE 87, and 5-chloro-2-thienyloxyacetic acid, EXAMPLE 24. 1H NMR (CD3OD300 MHz) δ8.68 (s, 1H), 8.27 (d, 1H), 7.62 (m, 2H), 6.54 (d, 1H), 6.18 (m, 1H), 7.39 (d, 1H), 4.94 (m, 4H), 4.15 (m, 2H), 3.76 (m, 2H), 3.44 (s, 3H), 3.10 (m, 2H), 1.28 (d, 3H).

Sources & evidence

ORD record
ord-bd1a8bcffe4d4e4ba7c2b43700f50b5a
Source dataset
uspto-grants-2009_11
Patent number
US07612075B2

Reaction notes

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