HCID 68897128, compound → HCID 68897867, compound

HRID 1433102Notes

Reaction equation

HRID 1433102 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][N:14]([CH2:17][C:18]2[CH:19]=[N:20][C:21]([NH:24][CH2:25][CH2:26][N:27]([CH3:29])[CH3:28])=[N:22][CH:23]=2)[C:13](=[O:30])[C@@H:12]1[CH2:31][O:32][CH3:33])=O)C1C=CC=CC=1>C(O)(=O)C.[Pd]>[CH3:29][N:27]([CH2:26][CH2:25][NH:24][C:21]1[N:22]=[CH:23][C:18]([CH2:17][N:14]2[CH2:15][CH2:16][NH:11][C@@H:12]([CH2:31][O:32][CH3:33])[C:13]2=[O:30])=[CH:19][N:20]=1)[CH3:28]

Participants

4

Reactant 1

HCID 68897128HCID 68897128, compound

Product 1

HCID 68897867HCID 68897867, compoundYield 31%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

4-Benzyloxycarbonyl-1-[(2-{[N,N-dimethylaminoethyl]-amino }-pyrimidin-5-yl)-methyl]-3-(S)-methoxymethyl-piperazine-2-one (0.01 g, 0.02 mmol) and 10% Pd on carbon (0.01 g) are stirred in acetic acid (3 mL) under a hydrogen atmosphere for 18 h. The mixture is filtered through Celite@ and is evaporated to provide the intermediate title compound as a clear colorless oil (0.002 g). MS (ES), 323 [M+H]+.

Workup

  1. filtrationThe mixture is filtered through Celite@
  2. customis evaporated

Sources & evidence

ORD record
ord-f759a0632a1d49b0acc27a5fc9cc366d
Source dataset
uspto-grants-2009_11
Patent number
US07612075B2

Reaction notes

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