反应详情

Phenyltrimethylammonium tribromide (7.5 g, 0.02 mol) was added portionwise to a stirred solution of 1-(2,4-Bis-benzyloxy-5-chloro-phenyl)-ethanone (7.09 g, 0.019 mol) in tetrahydrofuran (100 ml) and the mixture was stirred for 2 h. The mixture was partitioned between water (100 ml) and diethyl ether (2×50 ml). The combined organic phases were dried over magnesium sulphate and concentrated to give a beige solid. Crystallisation from toluene (100 ml) gave 1-(2,4-Bis-benzyloxy-5-chloro-phenyl)-2-bromo-ethanone as a white solid (4.5 g)

1. customThe mixture was partitioned between water (100 ml) and diethyl ether (2×50 ml)
2. dry with materialThe combined organic phases were dried over magnesium sulphate
3. concentrationconcentrated
4. customto give a beige solid
5. customCrystallisation from toluene (100 ml)