HRID1433163

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1c[nH]c2cc(OCc3ccccc3)c(C(=O)CN3CCN(C(=O)OCc4ccccc4)CC3)cc12

HCID57934816

未命名化合物

PRODUCTS

生成物

结构：Cc1c[nH]c2cc(OCc3ccccc3)c(C(=O)C(=CN(C)C)N3CCN(C(=O)OCc4ccccc4)CC3)cc12

HCID69060591

未命名化合物

收率 43%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID78373

Methanamine, 1,1-dimethoxy-N,N-dimethyl-

C5H13NO2

PROCEDURE

实验过程

A solution of 4-[2-(6-benzyloxy-3-methyl-1H-indol-5-yl)-2-oxo-ethyl]-piperazine-1-carboxylic acid benzyl ester (0.661 g, 1.33 mmol) in DMFDMA (5 ml) was heated at 100° C. overnight. The solvent was removed in vacuo and the crude product purified by column chromatography in hexane/EtOAc (1:1) to afford the product (0.158 g, 22%). LC/MS: RT=5.33 min. 553 (MH+).

WORKUP

后处理

customThe solvent was removed in vacuo
customthe crude product purified by column chromatography in hexane/EtOAc (1:1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c1e19cc227ec484eaef68e791d199131
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07612201B2
来源说明: uspto-grants-2009_11

反应 SMILES

[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([CH2:17][C:18]([C:20]2[CH:21]=[C:22]3[C:26](=[CH:27][C:28]=2[O:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[NH:25][CH:24]=[C:23]3[CH3:37])=[O:19])[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CN(C(OC)OC)C>[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]([C:18]([C:20]2[CH:21]=[C:22]3[C:26](=[CH:27][C:28]=2[O:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[NH:25][CH:24]=[C:23]3[CH3:37])=[O:19])=[CH:9][N:11]([CH3:16])[CH3:12])[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1