反应详情

Phenyltrimethylammonium tribromide (5.6 g, 0.015 mol) was added portionwise to a stirred solution of 1-(2,4-Bis-benzyloxyphenyl)-ethanone (5.0 g, 0.015 mol) in tetrahydrofuran (50 ml) and the mixture was stirred for 2 h. The mixture was partitioned between water (50 ml) and diethyl ether (2×50 ml). The combined organic phases were dried over magnesium sulphate and concentrated to give 1-(2,4-Bis-benzyloxyphenyl)-2-bromo-ethanone as a beige solid which was used without further purification.

1. customThe mixture was partitioned between water (50 ml) and diethyl ether (2×50 ml)
2. dry with materialThe combined organic phases were dried over magnesium sulphate
3. concentrationconcentrated