反应详情

Using the procedure for Step D in Example 1 (as described in J. Med. Chem., 1986, 29, 2280), the title compound was prepared from 4-bromo-benzene-1,2-diamine (200 mg, 1.07 mmol) and 2-chloroacetimidic acid ethyl ester hydrochloride salt (168 mg, 1.07 mmol) and was obtained as an off-white solid (240.3 mg, 92% yield). 1H NMR (400 MHz, CD3OD) δ (ppm): 7.75 (d, 1H, J=1.4 Hz), 7.47 (d, 1H, J=8.6 Hz), 7.74 (dd, 1H, J=8.6 Hz, J=1.3 Hz), 4.84 (s, 2H). Mass Spectrum (LCMS, ESI pos.) Calcd. For C18H20ClN3O2S: 247.50 (M+H), Found 247.0.