4-(Trifluoromethyl)phenol → HCID 178506219, compound

HRID 1433187Notes

Reaction equation

HRID 1433187 reaction equation
[Br:1][C:2]1[CH:12]=[CH:11][C:5]2[NH:6][C:7]([CH2:9]Cl)=[N:8][C:4]=2[CH:3]=1.[F:13][C:14]([F:23])([F:22])[C:15]1[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=1>>[Br:1][C:2]1[CH:12]=[CH:11][C:5]2[NH:6][C:7]([CH2:9][O:21][C:18]3[CH:17]=[CH:16][C:15]([C:14]([F:13])([F:22])[F:23])=[CH:20][CH:19]=3)=[N:8][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 678744-(Trifluoromethyl)phenolHCID 178478445HCID 178478445, compound

Product 1

HCID 178506219HCID 178506219, compound

Procedure

Using the procedure for Step E in Example 1, the title compound was prepared from 5-bromo-2-chloromethyl-1H-benzimidazole (200 mg, 0.816 mmol) and α,α,α-trifluoro-p-cresol (132 mg, 0.816 mmol) and was obtained as an off-white solid (76.2 mg, 25% yield). Calcd. For C21H16F3N3O3S: 371.15 (M+H), Found 371.0.

Sources & evidence

ORD record
ord-1977de3890c34e28af0a7fec05692087
Source dataset
uspto-grants-2009_11
Patent number
US07612211B2

Reaction notes

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