HRID1433244

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)N(CC[C@H](c1ccccc1)c1cc(/C=C/COc2ccc(CCNC(=O)OC(C)(C)C)cc2)ccc1OCc1ccccc1)C(C)C

HCID57933229

未命名化合物

HCID178418361

未命名化合物

PRODUCTS

生成物

结构：CC(C)N(CC[C@H](c1ccccc1)c1cc(CCCOc2ccc(CCNC(=O)OC(C)(C)C)cc2)ccc1O)C(C)C

HCID57933235

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

tert-Butyl[2-(4-{[(2E)-3-{4-(benzyloxy)-3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]phenyl}prop-2-en-1-yl]oxy}phenyl)ethyl]carbamate (Preparation 6, 475 mg, 0.70 mmol) was dissolved in ethanol (20 ml) and 10% palladium on carbon (50 mg) added. The reaction was heated to 40° C. under 50 psi of hydrogen for 4 hours. The reaction was cooled to room temperature and filtered through Arbocel™, the filtrate was collected and the solvent removed in vacuo to furnish the title compound as a glass, 400 mg.

WORKUP

后处理

filtrationfiltered through Arbocel™
customthe filtrate was collected
customthe solvent removed in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-98542ed07b9f48ac9409ae4f0a307d03
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07612084B2
来源说明: uspto-grants-2009_11

反应 SMILES

[C:1]([O:5][C:6](=[O:50])[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:17]/[CH:18]=[CH:19]/[C:20]2[CH:25]=[CH:24][C:23]([O:26]CC3C=CC=CC=3)=[C:22]([C@@H:34]([C:44]3[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=3)[CH2:35][CH2:36][N:37]([CH:41]([CH3:43])[CH3:42])[CH:38]([CH3:40])[CH3:39])[CH:21]=2)=[CH:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2].[H][H]>C(O)C.[Pd]>[C:1]([O:5][C:6](=[O:50])[NH:7][CH2:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([O:16][CH2:17][CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([OH:26])=[C:22]([C@@H:34]([C:44]3[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=3)[CH2:35][CH2:36][N:37]([CH:38]([CH3:39])[CH3:40])[CH:41]([CH3:43])[CH3:42])[CH:21]=2)=[CH:14][CH:15]=1)([CH3:2])([CH3:3])[CH3:4]