tert-Butyl[2-(4-{[(2E)-3-{4-(benzyloxy)-3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]phenyl}prop-2-en-1-yl]oxy}phenyl)ethyl]carbamate → tert-Butyl{2-[4-(3-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}propoxy)phenyl]ethyl}carbamate

Participants

Reaction Steps

tert-Butyl[2-(4-{[(2E)-3-{4-(benzyloxy)-3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]phenyl}prop-2-en-1-yl]oxy}phenyl)ethyl]carbamate (Preparation 6, 475 mg, 0.70 mmol) was dissolved in ethanol (20 ml) and 10% palladium on carbon (50 mg) added. The reaction was heated to 40° C. under 50 psi of hydrogen for 4 hours. The reaction was cooled to room temperature and filtered through Arbocel™, the filtrate was collected and the solvent removed in vacuo to furnish the title compound as a glass, 400 mg.

Provenance & Evidence