反应详情

Di-tert-butyl(7-{4-(benzyloxy)-3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]phenoxy}heptyl)imidodicarbonate (Preparation 17, 220 mg, 0.30 mmol) was dissolved in dichloromethane (6 ml) then hydrogen chloride (2M solution in diethyl ether, 6 ml, 12 mmol) was added and after 30 minutes, ethanol (1 ml) was added and left over night. The solvent was removed in vacuo to furnish the title compound as a pale brown foam, 190 mg.

1. waitleft over night
2. customThe solvent was removed in vacuo