Hydrochloric Acid → 7-{4-(benzyloxy)-3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]phenoxy}heptan-1-amine bis hydrochloride salt

HRID 1433253Notes

Reaction equation

HRID 1433253 reaction equation
C(OC([N:8]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([O:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[C:26]([C@@H:38]([C:48]2[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=2)[CH2:39][CH2:40][N:41]([CH:45]([CH3:47])[CH3:46])[CH:42]([CH3:44])[CH3:43])[CH:25]=1)C(OC(C)(C)C)=O)=O)(C)(C)C.[ClH:54].C(O)C>ClCCl>[ClH:54].[ClH:54].[CH2:31]([O:30][C:27]1[CH:28]=[CH:29][C:24]([O:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][NH2:8])=[CH:25][C:26]=1[C@@H:38]([C:48]1[CH:49]=[CH:50][CH:51]=[CH:52][CH:53]=1)[CH2:39][CH2:40][N:41]([CH:45]([CH3:46])[CH3:47])[CH:42]([CH3:44])[CH3:43])[C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 69008693Di-tert-butyl(7-{4-(benzyloxy)-3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]phenoxy}heptyl)imidodicarbonate

Product 1

HCID 866164817-{4-(benzyloxy)-3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]phenoxy}heptan-1-amine bis hydrochloride salt

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Di-tert-butyl(7-{4-(benzyloxy)-3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]phenoxy}heptyl)imidodicarbonate (Preparation 17, 220 mg, 0.30 mmol) was dissolved in dichloromethane (6 ml) then hydrogen chloride (2M solution in diethyl ether, 6 ml, 12 mmol) was added and after 30 minutes, ethanol (1 ml) was added and left over night. The solvent was removed in vacuo to furnish the title compound as a pale brown foam, 190 mg.

Workup

  1. waitleft over night
  2. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-3ffbf611e7b74e2aae6b447ca1ce753d
Source dataset
uspto-grants-2009_11
Patent number
US07612084B2

Reaction notes

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