HRID1433276

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CC(C)N(CC[C@H](c1ccccc1)c1cc(CCOc2ccc(CCNC(=O)OC(C)(C)C)cc2)ccc1OCc1ccccc1)C(C)C

HCID57933204

未命名化合物

PRODUCTS

生成物

结构：CC(C)N(CC[C@H](c1ccccc1)c1cc(CCOc2ccc(CCN)cc2)ccc1OCc1ccccc1)C(C)C.Cl.Cl

HCID86616485

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

tert-butyl{2-[4-(2-{4-(benzyloxy)-3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]phenyl}ethoxy)phenyl]ethyl}carbamate (Preparation 41, 3.4 g, 5.1 mmol) was dissolved in dioxan (20 ml) and treated with hydrochloric acid (4M in dioxan, 26 ml). After stirring for 4 hours at room temperature the solvent was removed in vacuo. The residue was azeotroped twice from dichloromethane to yield the title compound as a brown solid, 3.

WORKUP

后处理

customwas removed in vacuo
customThe residue was azeotroped twice from dichloromethane

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-47f3553978214ad4b41d80181f551a23
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07612084B2
来源说明: uspto-grants-2009_11

反应 SMILES

C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[C:21]([C@@H:33]([C:43]3[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=3)[CH2:34][CH2:35][N:36]([CH:40]([CH3:42])[CH3:41])[CH:37]([CH3:39])[CH3:38])[CH:20]=2)=[CH:12][CH:11]=1)(C)(C)C.[ClH:50]>O1CCOCC1>[ClH:50].[ClH:50].[NH2:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH2:26][C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)=[C:21]([C@@H:33]([C:43]3[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=3)[CH2:34][CH2:35][N:36]([CH:40]([CH3:42])[CH3:41])[CH:37]([CH3:39])[CH3:38])[CH:20]=2)=[CH:12][CH:11]=1