Ammonium formate → di-tert-butyl(8-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}octyl)imidodicarbonate

Participants

Reaction Conditions

Reaction Steps

di-tert-butyl[(7E)-8-{4-(benzyloxy)-3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]phenyl}oct-7-en-1-yl]imidodicarbonate (Preparation 51, 530 mg, 0.73 mmol), palladium hydroxide (20% by weight on carbon, 100 mg, 0.14 mmol) and ammonium formate (1.1 g, 17 mmol) were dissolved in ethanol (20 ml) and heated to 70° C. for 3 hours. Reaction mixture was cooled and filtered and the solvent removed in vacuo to yield the title compound as a clear oil, 340 mg.

Provenance & Evidence