HRID1433285

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2723923

Formic acid, ammonium salt

CH5NO2

结构：CC(C)N(CC[C@H](c1ccccc1)c1cc(/C=C/CCCCCCN(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)ccc1OCc1ccccc1)C(C)C

HCID57933221

未命名化合物

PRODUCTS

生成物

结构：CC(C)N(CC[C@H](c1ccccc1)c1cc(CCCCCCCCN(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)ccc1O)C(C)C

HCID57933172

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID9942167

Palladium hydroxide

H2O2Pd

溶剂HCID702

Ethanol

C2H6O

CONDITIONS

反应条件

温度: 70 °C

PROCEDURE

实验过程

di-tert-butyl[(7E)-8-{4-(benzyloxy)-3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]phenyl}oct-7-en-1-yl]imidodicarbonate (Preparation 51, 530 mg, 0.73 mmol), palladium hydroxide (20% by weight on carbon, 100 mg, 0.14 mmol) and ammonium formate (1.1 g, 17 mmol) were dissolved in ethanol (20 ml) and heated to 70° C. for 3 hours. Reaction mixture was cooled and filtered and the solvent removed in vacuo to yield the title compound as a clear oil, 340 mg.

WORKUP

后处理

customReaction mixture
temperaturewas cooled
filtrationfiltered
customthe solvent removed in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ce63464b2d254fcba55c2f1f5c4a762b
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07612084B2
来源说明: uspto-grants-2009_11

反应 SMILES

[C:1]([O:5][C:6]([N:8]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]/[CH:22]=[CH:23]/[C:24]1[CH:29]=[CH:28][C:27]([O:30]CC2C=CC=CC=2)=[C:26]([C@@H:38]([C:48]2[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=2)[CH2:39][CH2:40][N:41]([CH:45]([CH3:47])[CH3:46])[CH:42]([CH3:44])[CH3:43])[CH:25]=1)[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=[O:7])([CH3:4])([CH3:3])[CH3:2].C([O-])=O.[NH4+]>C(O)C.[OH-].[Pd+2].[OH-]>[C:1]([O:5][C:6]([N:8]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][C:27]([OH:30])=[C:26]([C@@H:38]([C:48]2[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=2)[CH2:39][CH2:40][N:41]([CH:45]([CH3:46])[CH3:47])[CH:42]([CH3:44])[CH3:43])[CH:25]=1)[C:9]([O:11][C:12]([CH3:13])([CH3:15])[CH3:14])=[O:10])=[O:7])([CH3:4])([CH3:3])[CH3:2]