1-Bromo-3-ethylpentane → (3S,5S)-3-(3-ethylpentyl)-3-methyl-5-phenylmorpholin-2-one

HRID 1433319Notes

Reaction equation

HRID 1433319 reaction equation
[CH3:1][C:2]1[C:3](=[O:14])[O:4][CH2:5][C@H:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1.Br[CH2:16][CH2:17][CH:18]([CH2:21][CH3:22])[CH2:19][CH3:20]>>[CH2:19]([CH:18]([CH2:21][CH3:22])[CH2:17][CH2:16][C@@:2]1([CH3:1])[C:3](=[O:14])[O:4][CH2:5][C@H:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[NH:7]1)[CH3:20]

Participants

3

Reactant 2

HCID 177638001-Bromo-3-ethylpentaneHCID 57467834(5S)-3-methyl-5-phenyl-5,6-dihydro-2H-1,4-oxazin-2-one

Product 1

HCID 57467831(3S,5S)-3-(3-ethylpentyl)-3-methyl-5-phenylmorpholin-2-one

Procedure

The title compound was prepared from (5S)-3-methyl-5-phenyl-5,6-dihydro-2H-1,4-oxazin-2-one (0.454 g, 2.39 mmol, see WO-A-02/051983) and 1-bromo-3-ethylpentane (see Bull. Soc. Chim. Fr., 1975, 201-205) according to the procedure outlined in Preparation 1. The total amount of compound synthesised was 0.07 g.

Workup

  1. customoutlined in Preparation 1
  2. customThe total amount of compound synthesised

Sources & evidence

ORD record
ord-2f46e269f0094cd99ab77d7207e2bf0b
Source dataset
uspto-grants-2009_11
Patent number
US07612226B2

Reaction notes

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