(Bromomethyl)cyclobutane → (3S,5S)-3-(cyclobutylmethyl)-3-methyl-5-phenylmorpholin-2-one

HRID 1433320Notes

Reaction equation

HRID 1433320 reaction equation
[CH3:1][C:2]1[C:3](=[O:14])[O:4][CH2:5][C@H:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1.Br[CH2:16][CH:17]1[CH2:20][CH2:19][CH2:18]1>>[CH:17]1([CH2:16][C@@:2]2([CH3:1])[C:3](=[O:14])[O:4][CH2:5][C@H:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[NH:7]2)[CH2:20][CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 2734658(Bromomethyl)cyclobutaneHCID 57467834(5S)-3-methyl-5-phenyl-5,6-dihydro-2H-1,4-oxazin-2-one

Product 1

HCID 57467832(3S,5S)-3-(cyclobutylmethyl)-3-methyl-5-phenylmorpholin-2-one

Procedure

The title compound was prepared from (5S)-3-methyl-5-phenyl-5,6-dihydro-2H-1,4-oxazin-2-one (1 g, 5.28 mmol, see WO-A-02/051983) and (bromomethyl)cyclobutane according to the procedure outlined in Preparation 1. The total amount of compound synthesised was 0.445 g.

Workup

  1. customoutlined in Preparation 1
  2. customThe total amount of compound synthesised

Sources & evidence

ORD record
ord-9cf3e34bd58e492b831420bab5ba832d
Source dataset
uspto-grants-2009_11
Patent number
US07612226B2

Reaction notes

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