反应详情

温度

100 °C

The 4-(4-aminophenoxy)-6-cyano-7-(2-methoxyethoxy)quinoline (100 mg) synthesized in Production Example 10 and phenyl N-(3-methylisoxazol-5-yl)carbamate (81 mg) were added to toluene (5 ml), then diisopropylethylamine (0.88 ml) was added and the mixture was heated and stirred at 100° C. for 2 hours. After cooling, the precipitated crystals were filtered and washed with an ethyl acetate: toluene (1:1) mixed solvent to obtain the title compound (102 mg).

1. temperaturethe mixture was heated
2. temperatureAfter cooling
3. filtrationthe precipitated crystals were filtered
4. washwashed with an ethyl acetate: toluene (1:1)
5. additionmixed solvent