反应详情

Ethyl (E)-3-[2-amino-4-(4-nitrophenoxy)-3-pyridyl]-2-propenoate (330 mg), palladium-carbon (10%, aqueous, 100 mg), methanol (5 ml) and tetrahydrofuran (5 ml) were stirred overnight at under a hydrogen atomsphere at 1 atmosphere. The palladium-carbon was filtered off, the filtrate was distilled off under reduced pressure, and then the residue was purified by silica gel column chromatography (ethyl acetate, followed by ethyl acetate:methanol=5:1) to obtain 43 mg of a white solid.

1. filtrationThe palladium-carbon was filtered off
2. distillationthe filtrate was distilled off under reduced pressure
3. customthe residue was purified by silica gel column chromatography (ethyl acetate, followed by ethyl acetate:methanol=5:1)