4-Fluorophenyl isocyanate → HCID 22936483, compound

HRID 1433453Notes

Reaction equation

HRID 1433453 reaction equation
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][C:9]([O:10][C:11]3[CH:17]=[CH:16][C:14]([NH2:15])=[CH:13][CH:12]=3)=[C:4]2[CH:3]=[CH:2]1.[F:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]=[C:26]=[O:27])=[CH:21][CH:20]=1>C(OCC)(=O)C>[F:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26]([NH:15][C:14]2[CH:16]=[CH:17][C:11]([O:10][C:9]3[CH:8]=[CH:7][N:6]=[C:5]4[NH:1][CH:2]=[CH:3][C:4]=34)=[CH:12][CH:13]=2)=[O:27])=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 709554-Fluorophenyl isocyanateHCID 22936495HCID 22936495, compound

Product 1

HCID 22936483HCID 22936483, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

After dissolving 90 mg of 4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline in ethyl acetate at room temperature, 0.05 ml of parafluorophenyl isocyanate was added dropwise. The precipitated white crystals were filtered out to obtain 65 mg of the target substance.

Workup

  1. filtrationThe precipitated white crystals were filtered out
  2. customto obtain 65 mg of the target substance

Sources & evidence

ORD record
ord-9ff1fc699cb746268b1b5f5d9707adf6
Source dataset
uspto-grants-2009_11
Patent number
US07612092B2

Reaction notes

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